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This does not change the reconstitution process, but it does mean the side effect profiles during dose escalation can differ

This will ensure all of the B12 is absorbed into your body

However, for self-injection we recommend the area around the belly button

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High-dose or prolonged pyridoxine supplementation can also lead to alterations in other nutrient levels, for example, extended use of large doses has been associated with reduced serum folate concentrations in some reports, which suggests a need to monitor nutritional balance during long-term therapy